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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

Comparison 11. combined regimen mifepristone/prostaglandin:single vs continuous prostaglandin.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 failure to achieve complete abortion 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 all oral vs vaginal & continuous oral 2 1581 Risk Ratio (M‐H, Fixed, 95% CI) 1.48 [1.01, 2.16]
1.2 all oral vs single vaginal 2 1578 Risk Ratio (M‐H, Fixed, 95% CI) 1.19 [0.83, 1.70]
1.3 vaginal & continuous oral vs single vaginal 2 1579 Risk Ratio (M‐H, Fixed, 95% CI) 0.80 [0.54, 1.19]
1.4 all oral vs vaginal & continuous oral </=49 days 1 476 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.57, 2.41]
1.5 all oral vs vaginal & continuous oral > 49 days 1 1004 Risk Ratio (M‐H, Fixed, 95% CI) 1.60 [1.00, 2.57]
1.6 all oral vs single vaginal >/=49 days 1 459 Risk Ratio (M‐H, Fixed, 95% CI) 1.29 [0.60, 2.74]
1.7 all oral vs single vaginal > 49 days 1 1014 Risk Ratio (M‐H, Fixed, 95% CI) 1.12 [0.73, 1.70]
1.8 vaginal & continuous oral vs single vaginal >/=49days 1 463 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.50, 2.40]
1.9 vaginal & continuous oral vs single vaginal > 49 days 1 1010 Risk Ratio (M‐H, Fixed, 95% CI) 0.70 [0.43, 1.13]
2 ongoing pregnancy at follow‐up 2   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
2.1 all oral vs vaginal & continuous oral 2   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.2 all oral vs single vaginal 2   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.3 vaginal & continuous oral vs single vaginal 2   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 nausea 1 4438 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.83, 1.12]
3.1 all oral vs vaginal & continuous oral 1 1481 Risk Ratio (M‐H, Fixed, 95% CI) 0.84 [0.65, 1.09]
3.2 all oral vs single vaginal 1 1478 Risk Ratio (M‐H, Fixed, 95% CI) 0.94 [0.72, 1.24]
3.3 vaginal & continuous oral vs single vaginal 1 1479 Risk Ratio (M‐H, Fixed, 95% CI) 1.12 [0.87, 1.45]
4 vomiting 1 4438 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.69, 1.21]
4.1 all oral vs vaginal & continuous oral 1 1481 Risk Ratio (M‐H, Fixed, 95% CI) 0.80 [0.49, 1.30]
4.2 all oral vs single vaginal 1 1478 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.53, 1.43]
4.3 vaginal & continuous oral vs single vaginal 1 1479 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.68, 1.74]
5 diarrhoea 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 all oral vs vaginal & continuous oral 1 1481 Risk Ratio (M‐H, Fixed, 95% CI) 1.83 [1.11, 3.01]
5.2 all oral vs single vaginal 1 1478 Risk Ratio (M‐H, Fixed, 95% CI) 2.09 [1.24, 3.53]
5.3 vaginal & continuous oral vs single vaginal 1 1479 Risk Ratio (M‐H, Fixed, 95% CI) 1.15 [0.63, 2.07]