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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

Comparison 13. prostaglandin alone vs combined regimen (all).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 failure to achieve complete abortion 5   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 all 5 678 Risk Ratio (M‐H, Fixed, 95% CI) 2.21 [1.70, 2.87]
1.2 all without Jain M800&TM 4 528 Risk Ratio (M‐H, Fixed, 95% CI) 2.40 [1.79, 3.20]
1.3 =/< 49 days gestation 1 155 Risk Ratio (M‐H, Fixed, 95% CI) 2.81 [0.79, 10.00]
1.4 > 49 days gestation 1 89 Risk Ratio (M‐H, Fixed, 95% CI) 2.93 [0.63, 13.76]
1.5 with metotrexate combined regime 2 133 Risk Ratio (M‐H, Fixed, 95% CI) 2.92 [1.79, 4.76]
2 side effects 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 nausea 3 377 Risk Ratio (M‐H, Fixed, 95% CI) 0.71 [0.56, 0.88]
2.2 vomiting 3 466 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.55, 1.00]
2.3 diarrhoea 4 527 Risk Ratio (M‐H, Fixed, 95% CI) 1.23 [0.95, 1.59]