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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

Comparison 16. combined regimen methotrexate/prostaglandin: timing of prostaglandin.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 failure to achieve complete abortion 3   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 misoprostol day 7 vs day 3 1 86 Risk Ratio (M‐H, Fixed, 95% CI) 0.14 [0.02, 1.10]
1.2 misoprostol day 5 vs day 3 2 387 Risk Ratio (M‐H, Fixed, 95% CI) 0.72 [0.36, 1.43]
1.3 misoprostol day 5 vs day 4 2 394 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.37, 1.48]
1.4 misoprostol day 4 vs day 3 2 393 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.52, 1.80]