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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

Creinin 1995 M800pv.

Methods randomisation according to computer‐generated random number table 
 numbered sealed, opaque envelopes 
 no blinding
Participants 86 pregnant women, ≤ 56 days of amenorrhoea, confirmed by ultrasound, San Francisco General Hospital 
 Exclusion criteria: previous use of vitamins/folates, hematocrit ≤ 0.30, white blood cell count <3000/uL, platelet count <100 000/uL, haemoglobin <10.0 mg/dL, aspartate aminotransferase >2 times normal or active liver disease, serum creatinine >1.5 mg/dL or active renal disease, inflammatory bowel disease, asthma, intolerance to the medication
Interventions methotrexate 50mg/m2 intramuscular followed by: 
 group 1: misoprostol 800mcg/vaginal after 3 days 
 group 2: misoprostol 800mcg/vaginal after 7 days
Outcomes complete abortion, duration of vaginal bleeding, side effects, change in beta‐HCG levels
Notes power calculation (80% power, significance level of 0.05) 
 no major complications occurred
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate