Creinin 2007.

Methods	computer generated random numbers, randomisation centrally, permuted block design with varying block sizes; randomisation after taking mifepristone ; no blinding; opaque envelopes
Participants	1128 women enrolled;mean age 27 years, women with no more than 63 days gestation (mean gestational age 51‐52 days gestation) and willing to follow‐up and with access to a telephone. Exclusion criteria: contraindications to mifepristone or misoprostol, Hbg< 10, IUD in place, on anticoagulants or with coagulopathy, active cervicits or currently breastfeeding. Gestational age confirmed by US. 4 academic centers in the USA; University of Pittsburgh, Oregon Health and Science University, Northwestern University, University of Southern California
Interventions	mifepristone 200mg followed by: group 1: within 15 minutes, 800mcg misoprostol vaginal group 2: 23‐25 hours later, 800mcg misoprostol vaginal
Outcomes	complete abortion; side‐effect; bleeding; acceptibility
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate