| Methods |
sealed, opaque envelopes
random assignment before misoprostol administration |
| Participants |
150 pregnant women </= 56 days of amenorrhoea, confirmed by ultrasound |
| Interventions |
group 1: mifepristone 200mg and misoprostol 800mcg/oral after 48 hours
group 2: mifepristone 200mg and misoprostol 400mcg after 48 hours plus 400mcg 2 hours later/oral |
| Outcomes |
changes in blood pressure, pulse rate and temperature
complete and incomplete abortion
ongoing pregnancy
side effects
bleeding pattern |
| Notes |
power calculation (5% significance level to detect a 20% reduction in incidence of side effects)
no mentioning of major complications |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
