| Methods |
randomisation into 3 groups
randomisation procedure not stated |
| Participants |
58 women, pregnant ≤ 10 weeks, confirmed by ultrasound, University Hospital Los Angeles, USA
Exclusion criteria: uterine infection, prior uterine bleeding, cervical dilatation, anaemia, cardiovascular or cerebral disease, allergy to misoprostol |
| Interventions |
group A: misoprostol 100mcg/vaginally/ 8 hourly to a maximum of 6 doses
group B: misoprostol 100mcg/vaginally/ 8 hourly to a maximum of 6 doses and tamoxifen 10mg/orally after the first dose of misoprostol
group C: misoprostol 100mcg/vaginally/ 8 hourly to a maximum of 6 doses and laminaria/intracervical immediately before the first dose of misoprostol
the dose of misoprostol was increased after the success rate was unsatisfactory after the first 26 women |
| Outcomes |
complete abortion, failure rate, side effects, mean number of doses of misoprostol used, time until passing of conceptus |
| Notes |
no mentioning of major complications |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
