Middleton 2005.

Methods	computer generated randomisation in blocs of 8; sealed envelopes
Participants	442 women < 56 days randomised;mean age 26 years; mean gestaional age 47 days; study conducted between December 2001‐ June 2004 at two clinics at University of Rochester; USA
Interventions	1‐2 days after mifepristone 200mg: group 1: misoprostol 800mcg buccal group 2: misoprostol 800mcg vaginal buccal: 2 tablets placed inside each cheek and remainders swallowed after 30 minutes; vaginal: all 4 tablets placed profond into the vagina with 1 finger
Outcomes	complete abortion, side effects, acceptability
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B‐unclear