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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

Ozeren 1999 MP800&MT.

Methods random number tables; sealed opaque envelopes, sequentially numbered
Participants 108 women ≤ 63 days of amenorrhoea confirmed by ultrasound, University hospital Trabzon, Turkey 
 exclusion criteria: 
 haemoglobin < 100 g/L, leucocytaemie, active liver disease, active renal disease, inflammatory bowel disease, history of methotrexate/ misoprostol intolerance
Interventions group 1. methotrexate 50mg/m2/imi 
 group 2: misoprostol 800mcg/pv 
 group 3: methotrexate 50mg/m2/imi and misoprostol 800mcg/pv after 3 days
Outcomes complete abortions, ongoing pregnancies, side effects
Notes no major complications were reported; 10/36 women in the misoprostol only group received additional misoprostol on day 4
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate