Methods |
random number tables; sealed opaque envelopes, sequentially numbered |
Participants |
108 women ≤ 63 days of amenorrhoea confirmed by ultrasound, University hospital Trabzon, Turkey
exclusion criteria:
haemoglobin < 100 g/L, leucocytaemie, active liver disease, active renal disease, inflammatory bowel disease, history of methotrexate/ misoprostol intolerance |
Interventions |
group 1. methotrexate 50mg/m2/imi
group 2: misoprostol 800mcg/pv
group 3: methotrexate 50mg/m2/imi and misoprostol 800mcg/pv after 3 days |
Outcomes |
complete abortions, ongoing pregnancies, side effects |
Notes |
no major complications were reported; 10/36 women in the misoprostol only group received additional misoprostol on day 4 |
Risk of bias |
Bias |
Authors' judgement |
Support for judgement |
Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |