WHO 1991.
Methods | randomisation at WHO, using random permutation block technique with block size of 8, random numbers were provided to each centre in a sealed envelope | |
Participants | multicentre; 10 mostly academic hospitals: Aberdeen, Havana, Hong Kong, Ljubljana, Milan, Shanghai, Singapore, Stockholm, Szeged, Wuhan. 385 women were randomised. inclusion criteria: amenorrhoea ≤ 49 days, regular cycles (25‐35 days) for last 3 months exclusion criteria: unsure about dates, intrauterine device in situ, hormonal contraception during last cycle and intention to start hormonal contraception before first period after abortion |
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Interventions | group 1: mifepristone 25mg/12 hourly/ 5 doses and gemeprost 1mg/vaginally 60 hours after the start of the treatment group 2: mifepristone 600mg/single dose and gemeprost 1mg/vaginally 60 hours after the start of the treatment | |
Outcomes | complete, incomplete, missed abortion, continuing pregnancy, side effects, bleeding pattern, haemoglobin and hormone levels | |
Notes | 1 woman received blood transfusion; not mentioned which group | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | Low risk | A ‐ Adequate |