| Methods |
randomisation at WHO, using random permutation block technique with block size of 9, tablets were disposed into labelled bottles, placebos were added to women receiving the lower dose so that all received 3 tablets) |
| Participants |
multicentre, Hospitals in Aberdeen, Edinburgh, Havana, Hong Kong, Ljubljana, Milan, Shanghai, Stockholm, Szeged, Tianjin, Wuhan
1182 pregnant women with a menstrual delay of 7‐28 days
inclusion criteria:
regular cycles (25‐35 days) for last 3 months, pregnancy confirmed by ultrasound
exclusion criteria: unsure about dates, intrauterine device in situ, hormonal contraception during last cycle and intention to start hormonal contraception before first period after abortion, contraindication to mifepristone/misoprostol, regular use of prescribed drugs |
| Interventions |
group 1: mifepristone 200mg/oral
group 2: mifepristone 400mg/oral
group 3: mifepristone 600mg/oral
and prostaglandin 1mg/vaginally after 48 hours (all) |
| Outcomes |
complete, incomplete, missed abortion, continuing pregnancy, side effects, haemoglobin levels, side effects |
| Notes |
3 women received blood transfusion; not mentioned which group |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
