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. 2011 Nov 9;2011(11):CD002855. doi: 10.1002/14651858.CD002855.pub4

WHO 2001 MI200/50.

Methods computer generated number sequence
Participants multicentre trial, 13 centres: Aberdeen, Chandigarh, Edinburgh, Havana, Hong Kong, Ljubljana, Lusaka, Shanghai, Singapore, Stockholm, Szeged, Tbilisi, Tianjin 
 1224 women <57 days pregnant 
 inclusion criteria: regular cycles, no hormonal contraception or IUD use before first menses after abortion 
 exclusion criteria: 
 medical contraindication for the study medication, history of thromboembolism, liver disease, pruritus in pregnancy, IUD in situ, breastfeeding, heavy smokers
Interventions group 1: mifepristone 50mg/po and gemeprost 0.5mg/pv on day 3 
 group 2: mifepristone 50mg/po and gemeprost 1.0mg/pv on day 3 
 group 3: mifepristone 200mg/po and gemeprost 0.5mg/pv on day 3 
 group 4: mifepristone 200mg/po and gemeprost 1.0mg/pv on day 3
Outcomes complete /incomplete/missed abortion, 
 side effects
Notes group 1: was discontinued as interim analysis showed below cut‐off results. 
 no blinding for gemeprost 
 7 women received blood transfusion (2 group 1, 2 group 2, 1 group 3, 2 group4)
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate