| Methods |
computer generated list of random numbers, sealed, opaque envelopes |
| Participants |
398 women, ≤ 7 weeks pregnant confirmed by ultrasound, University Hospital Vancouver, Canada
exclusion criteria: abnormal haematologic parameters |
| Interventions |
Phase 1:
group 1:
Tamoxifen 40mg/po and 800mcg misoprostol/pv > 48 hours
group 2: Methotrexate 50mg/m2 and misoprostol 800mcg/pv >96 hours
Phase 2:
group 1:
Tamoxifen 40 mg/day for 4 days (= total dose of 160mg) and misoprostol 800mcg/pv > 48 hours
group 2: Methotrexate 50 mg/m2 and misoprostol 800mcg/pv >96 hours |
| Outcomes |
failure rate, side effects, women's preference |
| Notes |
no major complications were reported |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
