| Methods |
computer generated list of random numbers, sealed, opaque envelopes |
| Participants |
100 women, ≤ 7 weeks pregnant confirmed by ultrasound, University Hospital Vancouver, Canada
exclusion criteria: abnormal haematologic parameters, systemic disease, intolerance to study medication |
| Interventions |
group 1:
methotrexate 50 mg/m2/po and misoprostol 600mcg/pv > 96 hours
group 2:
methotrexate 50 mg/m2/imi and misoprostol 600mcg/pv > 96 hours |
| Outcomes |
complete, incomplete abortion, side effects |
| Notes |
only data from phase 1 are included, phase 2 was non‐random
no major complications were reported |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
