Karabayir 2006.

Methods	Double‐blind, placebo‐controlled study. January 2004 to June 2004.
Participants	50 term infants with TTN. Inclusion criteria: Onset of tachypnoea within 6 h after birth. Persistence of tachypnoea for at least 12 h. Chest roentgenogram consistent with TTN. Infants were excluded if they had: A history of meconium aspiration or premature rupture of membranes. Other disorders likely to cause tachypnoea (polycythaemia, hypoglycaemia, sepsis, pneumonia, RDS and aspiration syndromes). A cardiac murmur on physical examination.
Interventions	IV furosemide 2 mg/kg or saline placebo.
Outcomes	Duration of supplemental oxygen requirement; the period of tachypnoea; time to discharge from hospital; and weight loss in the first 24 h of life and before discharge.
Notes	SSK, Bakirköy Maternity and Child Disease Education Hospital, Istanbul, Turkey.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Randomised controlled study design. Information reported insufficient for a judgment to be made.
Allocation concealment?	Unclear risk	Not stated. Information reported insufficient for a judgment to be made.
Blinding? All outcomes	Low risk	Double‐blind intervention.
Incomplete outcome data addressed? All outcomes	High risk	Not reported clearly in the text.
Free of selective reporting?	Unclear risk	There is no protocol to access so we do not know the original planned outcomes.
Free of other bias?	Unclear risk	Not mentioned clearly
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Infants are unaware of study interventions and they were randomly assigned in a double‐blind way to study groups.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinding of assessors was not mentioned clearly in the study report but as the authors stated it is a double‐blind study, that suggests personnel and assessors were blinded.