Kristjansson 1995.
Methods | Randomised prospective study, initially by Mansson, 1989 with 2 subsequent papers published with longer follow‐up: Kristjansson, 1995a (primary reference) and 1995b. Mansson 1989 Mean follow‐up: Ileal conduit 67 months, colonic conduit 66 months and caecal reservoir 62 months Drop‐outs: none Kristjansson 1995a (primary reference) Mean follow‐up: Ileal conduit 121 months, colonic conduit 117 months and caecal reservoir 132 months Drop‐outs: Only 56 patients of previous total 94 patients presented, no reason given. 38 drop‐outs Kristjansson 1995b Mean follow‐up: 150 months Drop‐outs: 5 patients for renal scarring study, 4 patients in bacteriuria study (patients declined to participate) |
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Participants | Incl: invasive bladder carcinoma, radical cystectomy and neurogenic bladder dysfunction Mansson 1989 n = 94 Sex: 71 male, 23 female Mean age: Ileal conduit 60 years, colonic conduit 60 years and caecal reservoir 51 years Kristjansson 1995a (primary reference) n = 56 Sex: 43 male, 13 female Mean age: Ileal conduit 60 years, colonic conduit 60 years, caecal reservoir 50 years Kristjansson 1995b n (renal scarring) = 32 n (bacteriuria) = 5 n (GFR in renal units with scarring) = 60 Sex: (no mention) Mean age: (no mention) |
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Interventions | I: Ileal conduit diversion ‐ refluxing II: Ileal conduit diversion ‐ non ‐ refluxing III: Colonic conduit diversion ‐ refluxing IV: Colonic conduit diversion ‐ non ‐ refluxing V: Caecal continent diversion ‐ non ‐ refluxing | |
Outcomes | Mansson 1989
I: Renal function ‐ glomerular filtration rate
II: Ureterointestinal anastomotic strictures
III: Urinary tract infections Kristjansson 1995a (primary reference) I: Renal function: glomerular filtration rate II: Ureterointestinal anastomotic strictures III: Urinary tract infections Kristjansson 1995b I: Renal scarring: Presence and grade (1‐3) II: Bacteriuria: Presence and location III: GFR in renal units with scarring |
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Notes | Further follow‐up presented by Kristjansson in 1995 Kristjansson 1995a was used as the primary study as this had a longer follow‐up compared to Mansson 1989 The outcomes in Kristjansson 1995b of the presence and location of bacteriuria were not included as the numbers who participated were very small: 3 with ileal conduit and 2 with colonic conduit. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | not stated |
Allocation concealment (selection bias) | Unclear risk | not stated |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | not stated |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | not stated |
Incomplete outcome data (attrition bias) All outcomes | High risk | In 10 patients the initial allocation to colonic conduit was changed to ileal because of colonic anomalies. To minimize imbalance between the two conduit groups, each case following an unplanned ileal diversion received a colonic conduit |