Table 3.
Biochemical values by etiology of ALT >1000 IU/L with comparisons made against ischemic hepatitis
| Biochemistry | Ischemic | Toxic | Obstructive | Viral |
|---|---|---|---|---|
| Platelets, ×109/L | ||||
| Mean ± SD | 164.1 ± 8.3 | 201.5 ± 11.7 | 244.2 ± 11.8 | 184.5 ± 12.6 |
| P value | — | 0.012 | <0.001 | 0.34 |
| Bicarbonate, mmol/L | ||||
| Mean ± SD | 18.9 ± 0.6 | 23.3 ± 0.7 | 25.0 ± 0.4 | 27.0 ± 0.7 |
| P value | — | 0.001 | <0.001 | <0.001 |
| Creatinine, μmol/L | ||||
| Mean ± SD | 178.7 ± 8.1 | 98.2 ± 11.2 | 73.4 ± 2.7 | 80.4 ± 3.9 |
| P value | — | <0.001 | <0.001 | <0.001 |
| Albumin, g/L | ||||
| Mean ± SD | 28.7 ± 0.6 | 35.8 ± 0.7 | 38.1 ± 0.6 | 36.1 ± 1.0 |
| P value | — | <0.001 | <0.001 | <0.001 |
| Prothrombin time, s | ||||
| Median (IQR) | 23.2 (18.9–31.0) | 19.6 (14.8–24.9) | 13.3 (12.8–15.0) | 14.0 (13.4–16.3) |
| P value | — | 0.005 | <0.001 | <0.001 |
| Bilirubin, μmol/L | ||||
| Median (IQR) | 21 (10–37) | 28 (14–64) | 43 (29–87) | 76 (36–155) |
| P value | — | 0.048 | <0.001 | <0.001 |
| ALT, IU/L | ||||
| Median (IQR) | 1451 (1166–2340) | 1591 (1162–3425) | 1199 (1055–1471) | 1790 (1244–2472) |
| P value | — | 0.19 | <0.001 | 0.23 |
| AST, IU/L (n = 64) | ||||
| Median (IQR) | 2442 (1509–3448) | 2086, 723–4731 | 2751, 822–3009 | 1148, 983–1580 |
| P value | — | 0.49 | 0.76 | 0.012 |
| ALP, IU/L | ||||
| Median (IQR) | 117 (76–199) | 124 (83–199) | 221 (166–316) | 189 (157–233) |
| P value | — | 0.91 | <0.001 | 0.003 |
| GGT, IU/L | ||||
| Median (IQR) | 108 (53–246) | 171 (79–375) | 581 (303–1068) | 245 (202–426) |
| P value | — | 0.009 | <0.001 | <0.001 |
| R‐factor | ||||
| Median (IQR) | 44.4 (22.8–81.4) | 48.6 (29.8–99.7) | 18.7 (13.8–27.7) | 29.1 (21.2–38.0) |
| P value | — | 0.13 | <0.001 | 0.033 |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, Aspartate aminotransferase; GGT, gamma‐glutamyltransferase; IQR, interquartile range.