Table 5.
Odds ratios (OR) and adjusted OR of 28‐day mortality in patients with ischemic hepatitis from univariate and multivariable logistic regression
| Univariate analysis | Full multivariable model† | Reduced multivariable model‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | OR | 95% CI | P | Adjusted OR | 95% CI | P | Adj. OR | 95% CI | P |
| Age ≥ 65 years | 6.4 | 3.6–11.4 | <0.001 | 3.5 | 1.1–10.6 | 0.030 | 3.0 | 1.3–7.2 | 0.014 |
| Male | 1.5 | 0.9–2.5 | 0.13 | 2.4 | 0.8–7.1 | 0.13 | — | — | — |
| Septic shock | 12.0 | 5.8–24.9 | <0.001 | 13.0 | 3.0–55.9 | 0.001 | 14.7 | 4.3–50.7 | <0.001 |
| Cardiogenic shock | 2.6 | 1.3–5.0 | 0.005 | 3.9 | 1.1–13.7 | 0.035 | 4.3 | 1.6–11.7 | 0.005 |
| History of COPD | 4.7 | 2.3–9.7 | <0.001 | 8.6 | 2.0–36.8 | 0.004 | 5.4 | 1.6–17.8 | 0.006 |
| History of CCF | 7.1 | 3.6–13.8 | <0.001 | 2.6 | 0.8–9.2 | 0.13 | — | — | — |
| History of CAD | 3.9 | 1.9–8.0 | <0.001 | 0.8 | 0.2–3.8 | 0.76 | — | — | — |
| History of diabetes mellitus | 2.0 | 1.1–3.7 | 0.031 | 0.3 | 0.1–1.0 | 0.044 | — | — | — |
| History of CKD | 3.9 | 1.7–8.8 | 0.001 | 0.3 | 0.1–1.3 | 0.11 | — | — | — |
| History of CVD | 3.5 | 1.3–9.0 | 0.010 | 2.3 | 0.4–12.1 | 0.33 | — | — | — |
| Platelets < 180 × 109/L | 2.1 | 1.2–3.6 | 0.006 | 0.7 | 0.2–2.2 | 0.57 | — | — | — |
| Creatinine ≥ 110 μmol/L | 16.6 | 8.5–32.5 | <0.001 | 2.9 | 0.9–9.2 | 0.070 | — | — | — |
| Prothrombin time ≥ 20 s | 8.4 | 4.3–16.4 | <0.001 | 3.5 | 1.0–11.7 | 0.042 | 3.7 | 1.5–9.2 | 0.006 |
| Albumin < 34 g/L | 6.6 | 3.5–12.3 | <0.001 | 1.2 | 0.4–4.0 | 0.74 | — | — | — |
| GGT < 135 IU/L | 2.8 | 1.7–4.9 | <0.001 | 0.5 | 0.2–1.6 | 0.26 | — | — | — |
| Bicarbonate < 22 mmol/L | 10.1 | 5.5–18.6 | <0.001 | 9.1 | 2.5–32.5 | 0.001 | 7.3 | 2.5–21.3 | <0.001 |
| Bilirubin < 22 μmol/L | 1.6 | 1.0–2.7 | 0.073 | 1.0 | 0.3–3.2 | 0.98 | — | — | — |
†
All variables with P < 0.1 on univariate analysis, as well as prespecified additional variables of age ≥65 years and gender, were entered into a full multivariable logistic regression model.
‡
The full multivariable model was entered into a backward stepwise logistic regression model with removal criterion P > 0.05, leaving a reduced model with all remaining variables with P < 0.05.
CAD, coronary artery disease; CCF, congestive cardiac failure; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVD, cerebrovascular disease; GGT, gamma‐glutamyltransferase.