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. Author manuscript; available in PMC: 2020 Apr 9.
Published in final edited form as: Immunohorizons. 2019 Jul 12;3(7):306–316. doi: 10.4049/immunohorizons.1900034

Figure 6. Early death of 2KO-Bcl6FC mice and autoAb production.

Figure 6.

(A) Survival curve for IL-2 KO and 2KO-Bcl6FC (IL-2 KO Foxp3-cre Bcl6-flox cKO) mice over time. A Gehan-Breslow-Wilcoxon test was used to measure the statistical difference between the samples. (B-C) Serum samples were collected from 5 week old WT, IL-2 KO, Bcl6FC and 2KO-Bcl6FC mice for anti-dsDNA antibody detection by ELISA. (B) Anti-dsDNA IgM and (B) anti-dsDNA IgG titers are shown. The X-axis labels are dilution factors. Data shown as mean ± SEM, n=4 for WT, IL-2 KO, Bcl6FC and n=3 for 2KO-Bcl6FC. P values were calculated by T-test where * p < 0.05, ** p < 0.01, *** p < 0.0001.