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. Author manuscript; available in PMC: 2020 Apr 9.
Published in final edited form as: Immunohorizons. 2019 Jul 12;3(7):306–316. doi: 10.4049/immunohorizons.1900034

Figure 7. Increased auto-Abs in Bcl6FC mice.

Figure 7.

Serum from naïve WT and Bcl6FC mice was used to analyzed for anti-dsDNA Abs by ELISA and autoAg microarray. (A-B) Serum from 20 week old mice was tested for (A) anti-dsDNA IgG and (B) anti-dsDNA IgA. P values were calculated by t test where * p < 0.05, ** p < 0.01, *** p < 0.0001. N = 6 mice, experiment was repeated at 2 times. (C) Serum from 5 week old mice was tested for anti-autoAg IgG by microarray. 38 autoAgs out of 118 autoAgs tested showed a significant difference in IgG reactivity between WT and Bcl6FC, and all 38 showed a higher score for the Bcl6FC sera. All Graphs show selected anti-autoAg IgG scores for anti-collagen V, anti-Hmgb1, anti-DNA polymerase beta and anti-Histone H2B taken from the autoAg array data. P values were calculated by t test where ** p < 0.01. N = 4 mice.