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. 2019 Sep 8;16(5):946–955. doi: 10.1080/15548627.2019.1664144

Figure 1.

Figure 1.

Determination of antigen-presenting potential of synovial fibroblasts (SFs) and B cells. SFs and B cells were left untreated or treated with 100 ng/mL IFNG for 72 h. Cell surface expression of human leukocyte antigen (HLA)-DR and that of B7 costimulatory molecules were analyzed by flow cytometry. Histograms are representative of 3 independent experiments using cells from 3 different patients (A). Cell surface expression levels of the molecules were quantified and presented as mean fluorescent intensity (MFI) compared to isotype controls (B). SFs were left untreated or treated with 100 ng/mL IL6 plus soluble IL6RA/IL-6R for 72 h. Cell surface expression of HLA-DR and that of B7 costimulatory molecules were analyzed by flow cytometry. Histograms are representative of 3 independent experiments using cells from 3 different patients (C). MFI of C (D). Values are presented as mean ± S.D. * = P < 0.05.