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Deletion of the −35 or −44 kb CRE from the CFTR locus has a major impact on locus architecture. (A) 4C-seq interaction profiles of the same WT, Δ −35 kb (Clone #6) and Δ-44 kb (clone #4) 16HBE14o- clones shown in Figure 3, using viewpoints at the CFTR promoter and the −80.1 kb 5′ TAD boundary. The interpretation of the 4C-seq data is as described in the legend to Figure 2. Features of interest are shown by black or gray arrows or bars.
