Table 2.

Thermodynamic parameters for the TBA G-quadruplex and its pyrene-modified analogues

Oligonucleotide	ΔH° (kcal mol−1)	TΔS° (kcal mol−1)	ΔG°25 (kcal mol−1)	Tm (°C)
TBA	−39.2 ± 1.5	−35.6 ± 1.3	−3.6 ± 0.2	52.0
TBA4	−44.2 ± 6.8	−39.7 ± 6.3	−4.5 ± 0.5	57.6
TBA9M	−37.2 ± 4.4	−33.1 ± 4.1	−4.1 ± 0.4	58.4
TBA13	−42.2 ± 4.8	−37.8 ± 4.4	−4.5 ± 0.4	56.8