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. 2020 Jan 30;48(7):3848–3868. doi: 10.1093/nar/gkaa066

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Previous and new models for the yeast U3 snoRNA/pre-ribosomal RNA interaction. (Top) The 5′-terminal sequence of U3 snoRNA was previously proposed to form five base-pair interactions with the pre-rRNA. They were respectively designated as helices I, II, III, V and VI in yeast (9,10,28,30–32,34–36). (Bottom) Based on cryo-EM studies, an alternative model including three of the previously proposed interactions (helices II, V with an extension represented in red and VI) and an alternative helix III (represented in red) was established (40,44).