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Production of TAFC is impaired by HapX-deficiency as well as deletion of the HapX CBC-BD or mutations within the HapX DNA-BD in vivo. (A) TAFC production of the mutant strains was significantly reduced compared to wt and venushapX under iron starvation (P <0.001). (B) HapX-CBC as well as HapX-DNA interaction is crucial for activation of genes that promote TAFC biosynthesis in A. fumigatus.
