Table 2.
PANTHER analysis of mRNAs upregulated in ΔN-RNMT expressing cells
| PANTHER protein class | REFLIST (20996) | #up with ΔN-RNMT | Expected | Fold enrichment | Raw P-value | FDR |
|---|---|---|---|---|---|---|
| Ubiquitin-protein ligase | 98 | 27 | 10.88 | 2.48 | 1.19 × 10−4 | 2.13 × 10−3 |
| Ligase | 252 | 54 | 27.98 | 1.93 | 3.19 × 10−5 | 7.61 × 10−4 |
| Chromatin/chromatin-binding protein | 122 | 30 | 13.54 | 2.21 | 3.16 × 10−4 | 4.85 × 10−3 |
| DNA binding protein | 469 | 89 | 52.07 | 1.71 | 8.40 × 10−6 | 3.61 × 10−4 |
| Nucleic acid binding | 1599 | 279 | 177.52 | 1.57 | 4.04 × 10−12 | 8.69 × 10−10 |
| mRNA splicing factor | 109 | 25 | 12.10 | 2.07 | 2.08 × 10−3 | 2.23 × 10−2 |
| mRNA processing factor | 150 | 38 | 16.65 | 2.28 | 2.33 × 10−5 | 6.25 × 10−4 |
| RNA binding protein | 636 | 111 | 70.61 | 1.57 | 2.26 × 10−5 | 6.93 × 10−4 |
| Kinase modulator | 137 | 31 | 15.21 | 2.04 | 7.00 × 10−4 | 1.00 × 10−2 |
| Transcription cofactor | 167 | 35 | 18.54 | 1.89 | 1.29 × 10−3 | 1.63 × 10−2 |
| Transcription factor | 1156 | 191 | 128.34 | 1.49 | 5.02 × 10−7 | 5.39 × 10−5 |
| Kinase | 368 | 65 | 40.86 | 1.59 | 8.65 × 10−4 | 1.16 × 10−2 |
| Transferase | 866 | 144 | 96.14 | 1.50 | 1.03 × 10−5 | 3.69 × 10−4 |
The upregulated genes in Supplementary Table S2 were analyzed by PANTHER as in Table 1 using Fisher's Exact Test with False Discovery Rate correction.