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. 2020 Mar 17;11(3):e00150. doi: 10.14309/ctg.0000000000000150

Figure 2.

Figure 2.

Alterations in the abundances of gut microbial genera in CCP. (a), Six genera whose abundances had the greatest reductions in CCP patients relative to HCs, with comparisons by a two-tailed Wilcoxon signed-rank test (sum of the mean <2.3, difference of the mean >2.5, see Table 2, Supplementary Digital Content 1, http://links.lww.com/CTG/A229). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. (b), The AUROC curve analysis of the performance of 6 genera in the diagnosis of CCP. Faecalibacterium: AUC = 0.80 (0.68–0.80, P < 0.001), Subdoligranulum: AUC = 0.65 (0.52–0.65, P < 0.05), Phascolarctobacterium: AUC = 0.71 (0.59–0.71, P < 0.01), Bifidobacterium: AUC = 0.65 (0.51–0.65, P = 0.07), Collinsella: AUC = 0.67 (0.54–0.67, P < 0.67) Eubacterium: AUC = 0.70 (0.56–0.70, P < 0.01). The use of each of the 6 individual arcsine square root transformed abundance values, together with the coefficients from multivariate logistic regression: AUC = 0.92 (0.84–0.92, P < 0.001). AUC, area under curve; CCP, children with chronic pancreatitis; HC, healthy control.