Table 1. Loci, gene-sets, and leading edge genes associated with the number of services required to successfully conceive and maintain pregnancy (TBRD) for 300 crossbred Angus/Salers heifers.
| Association Test | BTA /Gene Set1 | Significance2 | Positional Candidate Genes/Leading Edge Genes3 |
|---|---|---|---|
| GWAA | 19(17) | 8.97 × 10−06 | ASIC2, SPACA3 |
| GSEA-SNP | GO: 0016705 | NES = 3.15 | MICAL2, PAH, PTGS1, CYP2D14, PHYH, DBH, P4HA3, CYP19A1, HMOX1 |
1Bos taurus (BTA) chromosome location of the loci associated with fertility followed by the location of the associated SNP in megabases (Mb) in parentheses for GWAA; for GSEA-SNP the enriched gene set was from Gene Ontology (GO).
2The significance (P < 1 × 10−5) was taken from the Wellcome Trust Case Control Consortium, 2007 for uncorrected P values for the GWAA; for the GSEA-SNP significance was determined by a normalized enrichment score (NES >3.0)
3Positional candidate genes were defined as genes located within 28.4 kb of the associated SNP(s) and leading edge genes were the genes positively influencing the enrichment scores for the gene set. Gene locations were based on UMD 3.1.