Fig 1. Cardiac dilatation in mice subjected to ACF.

(A) Partial oxygen pressure and oxygen saturation at the vena cava one day post-surgery (n = 6 mice per group). (B) Masson's trichrome–stained transverse cardiac sections four weeks post-surgery (representative captures). Scale bar: 1 mm. (C) Representative echocardiographic M-mode images of the same animals. (D) Expression profile of collagen proteins in cardiac sections of sham and ACF animals according to mass spectra analysis. The color scale is ranging from blue (reduced expression) to red (induced expression). (E) Cytochrome C oxidase activity in isolated mitochondria from sham and ACF hearts (n = 5 per group). Data are given as means ± SEM; * P < 0.05, **P < 0.01; ***P < 0.001.