Table 2.
MIC values (mg/L) of C-terminal 1-aminoethyltetrazole containing dipeptides 14a,d-j; NCTC: National Collection of Type Cultures, Colindale, UK; ATCC: American Type Culture Collection, Manassas, United States; NT: not tested; a: inoculum 150000 CFU/spot; b: inoculum 10000 CFU/spot; c: the tested compound was prepared by solution phase peptide coupling; d: the tested compound was prepared by solid phase peptide coupling.
| MIC (mg/L) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 14a-LL ac | 14a-LD ad | 14d-L ac | 14e-LL ac | 14h-LD ad | 14i-LL ad | 14f-LL ac | 14b-LL ad | 14g-L bd | 14h-LL bc | 14j-LL bd | ||
| Gram-negative species | Strain code | Ala- | Ala- | β-Ala- | Nor- | Leu- | Ile- | Pyr- | Ala- | Gly- | Leu- | Phe- |
| Acinetobacter baumannii | ATCC 19606 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 |
| Burkholderia cepacia | ATCC 25416 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | ≤ 1 |
| Enterobacter cloacae | NCTC 11936 | ≤1 | >128 | >128 | ≤1 | >128 | 4 | >128 | 8 | 32 | ≤1 | 8 |
| Escherichia coli | NCTC 10418 | ≤1 | >128 | >128 | ≤1 | >128 | 8 | >128 | >128 | >128 | ≤1 | 4 |
| Klebsiella pneumoniae | NCTC 9528 | ≤1 | >128 | >128 | ≤1 | >128 | >128 | 8 | >128 | >128 | 2 | 16 |
| Providencia rettgeri | NCTC 7475 | >128 | >128 | 128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 |
| Pseudomonas aeruginosa | NCTC 10662 | 64 | >128 | >128 | 64 | >128 | 128 | >128 | >128 | >128 | 64 | >128 |
| Salmonella Typhimurium | NCTC 74 | >128 | >128 | >128 | 2 | >128 | 128 | >128 | >128 | >128 | 64 | >128 |
| Serratia marcescens | NCTC 10211 | 2 | >128 | >128 | ≤1 | >128 | 16 | 8 | >128 | >128 | ≤1 | 8 |
| Yersinia enterocolitica | NCTC 11176 | ≤1 | >128 | >128 | ≤1 | >128 | 2 | 4 | >128 | 128 | ≤1 | NT |
| Escherichia coli | NCTC 12241 | ≤1 | >128 | >128 | ≤1 | >128 | 2 | >128 | >128 | 64 | ≤1 | 4 |
| Salmonella Enteritidis | NCTC 6676 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 |
| Gram-positive species | ||||||||||||
| Enterococcus faecalis | NCTC 775 | >128 | >128 | >128 | ≤1 | >128 | > 128 | 2 | >128 | >128 | 2 | 2 |
| Enterococcus faecium | NCTC 7171 | >128 | >128 | >128 | 2 | >128 | 64 | 2 | >128 | >128 | 16 | 32 |
| Listeria monocytogenes | NCTC 11994 | >128 | >128 | >128 | 4 | >128 | >128 | >128 | >128 | >128 | >128 | >128 |
| Staphylococci epidermidis | NCTC 11047 | > 128 | >128 | >128 | 2 | >128 | >128 | >128 | >128 | >128 | 2 | >128 |
| Staphylococcus aureus | NCTC 6571 | >128 | >128 | 64 | 4 | 128 | 128 | >128 | >128 | 64 | 16 | ≤1 |
| Staphylococcus aureus (MRSA) | NCTC 11939 | >128 | >128 | 128 | >128 | >128 | >128 | >128 | >128 | >128 | 8 | >128 |