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. 2020 Feb 24;19(7):758–771. doi: 10.1080/15384101.2020.1729450

Figure 2.

Figure 2.

Compounds screening in reference to GSK126-EZH2 interaction. (a, b) The binding mode of GSK126 to EZH2. (c) The purple spheres indicate the docking sites for virtual screening. Orange cube indicates the location and size of the grid to be calculated. Salmon spheres indicate the surface of amino acids 500–700 region. (d) The five putative EZH2 inhibitors were successfully docked into the defined binding pocket.