Secondary Outcomes from Dulai Prediction Models
			Low probability	Intermediate probability	High probability	p-value
Drug exposure	Pre-Dose VDZ Concentrations (ug/mL) by Probability of Response
	Week 2	UC	22.9	27.4	32	<0.001
		CD	24.7	28.45	32.7	<0.001
	Week 6	UC	17.2	23.5	34.9	<0.001
		CD	15.3	23.5	33.4	<0.001
	Week 22	UC	18.0	23.8	32.5	<0.001
		CD	15.8	23.4	30.3	<0.001
	Week 46	UC	22.5	27.8	31.5	0.016
		CD	18.7	25.8	32.6	0.0008
Onset of action	Change in Partial Mayo Score (UC) or Harvey-Bradshaw Index (CD) from Baseline by Probability of Response
	Week 6	UC	−1.22	−1.89	−2.21	<0.001
		CD	−1.69	−2.61	−4.22	<0.001
	Week 22	UC	−2.68	−3.2	−3.75	0.003
		CD	−3.76	−4.53	−5.82	<0.001
	Week 38	UC	−3.24	−4.21	−4.13	0.002
		CD	−4.62	−5.57	−6.76	<0.001
	Week 52	UC	−3.64	−4.42	−4.33	0.029
		CD	−4.68	−6.32	−7.17	<0.001

AUROC, Area Under Receiver Operator Curse; CSFR, Corticosteroid-Free Remission; CSFER, Corticosteroid-Free Endoscopic Remission; CREM, Clinical Remission; CSF-REM, Corticosteroid-free Remission; MH, Mucosal Healing; DR, Deep Remission.

Dulai et al. CDST for CD Probability of response: Low (Intermediate ≤ 13), Intermediate (>13 to ≤19 points), High (>19 points).

Dulai et al. CDST for UC Probability of response: Low (≤ 26 points), Intermediate (>26 to ≤32 points), High (>32 points).