Table 5. Criteria recommended by 2017 ATS Guidelines for rapid molecular drug susceptibility testing for rifampina.
Criteria | All TB patientsb | DS-TB | Non-MDR/RMP drug resistance | MDR/RMP-R TB | MDR/RMP-R TB vs DS-TB | MDR/RMP-R TB vs non-MDR/RMP drug resistance | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(n=485) | % | (n=306) | % | (n=49) | % | (n=47) | % | OR | (95% CI) | p-value | OR | (95% CI) | p-value | |
Previous TB treatment | 70 | 14.4 | 26 | 8.5 | 9 | 18.4 | 16 | 34.0 | 5.39 | (2.57–11.3) | <0.001 | 2.21 | (0.83–5.90) | 0.112 |
Born or lived less than one year in higher risk country | 428 | 88.2 | 264 | 86.3 | 43 | 87.8 | 45 | 95.7 | 2.72 | (0.62–11.2) | 0.184 | 3.02 | (0.56–16.2) | 0.197 |
Contact of MDR-TB | 4 | 0.8 | 1 | 0.3 | 2 | 4.1 | 1 | 2.1 | 9.04 | (0.54–148.7) | 0.123 | 0.46 | (0.03–5.60) | 0.548 |
HIV infection | 10 | 2.1 | 6 | 2.0 | 0 | 0.0 | 4 | 8.5 | 4.26 | (1.06–17.0) | 0.04 | N/A | N/A | N/A |
Abbreviations: ATS, American Thoracic Society; DS, drug-susceptible; HIV, human immunodeficiency virus; MDR, multidrug resistant; N/A, not applicable; R, resistance, RMP, rifampin; TB, tuberculosis
a Rapid molecular drug susceptibility testing for rifampin by drug resistance pattern (A) and multivariable analyses comparing MDR/RMP-R TB with drug susceptible TB (B) and non-MDR/RMP drug resistant TB (C)
b TB incidence of ≥20/100,000 or primary MDR prevalence of ≥2%