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. Author manuscript; available in PMC: 2020 Sep 30.
Published in final edited form as: Nat Genet. 2020 Mar 30;52(4):401–407. doi: 10.1038/s41588-020-0599-0

Extended Data Fig. 7:

Extended Data Fig. 7:

Mendelian randomization results on causality of IOP over refractive error. Single points in the graph represent coordinates determined by the effect of each specific SNP over IOP (x-axis, mmHg) and spherical equivalent (y-axis, Diopter units). A total of 73 SNPs associated with IOP, but not directly associated with refractive error (i.e. p> 0.05) were selected as instruments. Values of associations with IOP were obtained from a meta-analysis of 139,555 European participants (Reference 50 in the manuscript) and the refractive error associations from 102,117 UK Biobank subjects. The lines represent the regression lines from each model, as specified in the figure legend. In some cases, these lines may not visible because they overlap (please refer to the values underneath the figure).