Table 1.
Improvements in ChiTaRS 5.0: significant enhancement over previous database editions
| Content | ChiTaRS | ChiTaRS 2.1 | ChiTaRS 3.1 | ChiTaRS 5.0 | Relevance |
|---|---|---|---|---|---|
| The collection of chimeric transcripts | 16282 (total), 9379 (Homo sapiens), 4828 (Mus musculus), 2055 (D. melanogaster) | 29164 (total), 20 753 (Homo sapiens), 6226 (M. musculus), 2151 (D. melanogaster), 4 (Bos taurus), 8 (Rattus norvegicus), 4 (Danio rerio), 5 (S. cerevisiae), 13 (Sus scrofa) | 34 922 (total), 24 608 (Homo sapiens), 7457 (M. musculus), 2740 (D. melanogaster), 6 (Bos taurus), 10 (Rattus norvegicus), 7 (Danio rerio), 5 (S. cerevisiae), 89 (Sus scrofa) | 111 582 (total), 66 243 (Homo sapiens), 41 584 (M. musculus), 3052 (D. melanogaster), 19 (Bos taurus), 20 (Rattus norvegicus), 67 (Danio rerio), 305 (S. cerevisiae), 292 (Sus scrofa) | Extension of the collection for all eight organisms by ∼76 600 new entries |
| Disease Breakpoints | 1280 | 1428 | 11 714 | 23 167 | Extension by >11 000 new entries to include unique fusion transcripts with breakpoint information associated with cancer and other complex diseases |
| Manually verified breakpoints | 456 | 1428 | 10 285 | 11 650 | Additional breakpoints verified manually |
| Druggable fusions | No | No | No | 680 | A novel feature providing information on the use of the chimeric breakpoint as a drug target |
| Hi–C (3D Chromatin Contact Map) chimeras | No | No | No | 5597 | The addition of ∼5600 chimeras, now matched with 3D chromatin contact maps from Hi–C data |
| Chimeric Protein-Protein interaction (ChiPPI) networks | No | No | 2081 (validated), 22527 (predicted) | 9973 (validated), 42 058 (predicted) | Additional protein-protein network analysis maps for ∼27 000 chimeras |
| RNA-seq verified chimeras | 175 | 337 | 435 | 937 | Extension of the number of chimeras verified in RNA-seq experiments by ∼500 |
| Sense-antisense chimeras | No | 6044 | 6485 | 7521 | The incorporation of ∼1000 additional sense-antisense chimeras |
| Chimeras identified in cell-lines | No | No | No | 2411 | The identification of ∼2400 chimeras across 531 human cell lines |
| Links to external data repositories (GeneCards, OMIM, Pubmed, Ensembl, SNOMED CT & RefSeq) | No | No | 33 124 | 136 458 | The addition of ∼100 000 links to multiple data repositories for ease of correlation |