Table 2.
List of chimeric RNAs frequently being used as drug targets
| S.No. | Drug | Gene fusion | References (PubMed ID) |
|---|---|---|---|
| 1 | Alectinib | EML4-ALK | 25228534, 28890946 |
| 2 | ATRA + ATO | PML-RARA | 15103387 |
| 3 | AZD4547 | FGFR1-TACC1 | 28890946 |
| 4 | Crizotinib | RANBP2-ALK | 20979472, 28890946 |
| EML4-ALK | |||
| PTPRZ1-MET | 27748748, 28890946 | ||
| 5 | Dasatinib | BCR-ABL1 | 19779040, 21562040 |
| RCSD1-ABL1 | 21863287, 21562040 | ||
| 6 | Entrectinib | TPM3-NTRK1 | 24705251, 28890946 |
| ETV6-NTRK3 | |||
| VCL-NTRK2 | |||
| AGBL4-NTRK2 | |||
| 7 | Erdafinitib | FGFR3-TACC3 | 28890946 |
| 8 | Foretinib | PTPRZ1-MET | 27748748 |
| CLIP2-MET | |||
| TFG-MET | |||
| 9 | Imatinib | FIP1L1-PDGFRA | 12660384, 16089297 |
| BCR-PDGFRA | 15034867, 11423618 | ||
| EML1-ABL1 | 15713800, 28890946 | ||
| NUP214-ABL1 | 16213363, 28890946 | ||
| COL1A1-PDGFB | 20194851, 28890946 | ||
| BCR-ABL1 | 28890946, 11423618 | ||
| 10 | Lapatinib | TENM4-NRG1 | 24727320 |
| 11 | Larotrectinib | TPM3-NTRK1 | 28890946, 29606586 |
| 12 | Nilotinib | BCR-ABL1 | 21562040, 28890946 |
| 13 | Ponatinib | FGFR1-TACC1 | 29617662 |
| 14 | Sorafenib | SLC45A3-BRAF | 20526349, 24727320 |
| 15 | Trastuzumab | ERBB2-CLDN7 | 28890946 |