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. 2019 Oct 15;22(11):735–745. doi: 10.1093/ijnp/pyz054

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© The Author(s) 2019. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — LY-2456302 attenuates U50,488-induced increases in ICSS stimulation thresholds and decreases in maximum rates of responding. LY-2456302 was administered p.o. 30 minutes before injection of U50,488 (10 mg/kg, i.p.). Shown are effects on (a) ICSS stimulation thresholds (Theta 0) and (b) maximum rates of operant responding for: Veh + Veh (n = 9), Veh + U50 (n = 8), and LY-2456302 [1 mg/kg (n = 5), 10 mg/kg (n = 5), and 30 mg/kg (n = 5)] + U50. ICSS thresholds and rates of responding were measured for a total of 90 minutes and data are presented as percent pre-drug baseline. ##P < .01 comparing [Veh + U50] to [Veh + Veh]; **P < .01 comparing [LY (30) + U50] to [Veh + U50] (a), and [LY (10) and LY (30) + U50] to [Veh + U50] (b). LY-2456302 (30 mg/kg, n = 5) on its own had no effect on ICSS thresholds (c) or maximum rates of responding (d) over the 90-minute session. (e) No dose of LY-2456302 significantly altered percent baseline ICSS thresholds in the first 30 minutes post-LY injection, but before Veh was injected at 30 minutes: LY-2456302 [Veh (n = 9), 1.0 mg/kg (n = 5), 10.0 mg/kg (n = 5), 30 mg/kg (n = 8)]. (f) Average of changes in percent baseline ICSS thresholds for each treatment from 30 to 90 minutes post-LY-2456302 treatment, including LY-2456302 (1.0 mg/kg, n = 5). **P < .05 compared with Veh + U50.