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. 2019 Jul 24;47(16):8595–8605. doi: 10.1093/nar/gkz608

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Pif1, but not RPA, aids Pol δ in DNA synthesis through hTelo and cMyc G-quadruplexes. (A) Schematic of the primer extension reaction scheme. (B) Representative primer extension assay results for Pol δ^DV alone (black) and in the presence of either RPA (red) or Pif1 (blue) or both (green), with cMyc (left) or hTelo (right) in the template strand. Quantifications of the fraction of full-length product generated as a function of time are shown in (C) for Pol δ^DV and (D) for Pol δ.