Table 2.
Summary of prioritized candidate genes in Gene4Denovo database
| Disease (trios) | FDR ≤ 0.0001 | 0.0001< FDR ≤ 0.001 | 0.001 < FDR ≤ 0.01 | 0.01 < FDR ≤ 0.05 | 0.05 < FDR ≤ 0.1 | 0.1 < FDR < 0.2 |
|---|---|---|---|---|---|---|
| ASD (6511) | 13 | 9 | 10 | 29 | 26 | 53 |
| UDD (4293) | 85 | 21 | 43 | 50 | 40 | 69 |
| CHD (2645) | 3 | 3 | 4 | 12 | 13 | 25 |
| ID (1331) | 26 | 13 | 18 | 16 | 14 | 34 |
| EE (933) | 14 | 3 | 14 | 12 | 8 | 29 |
| SCZ (1094) | 0 | 0 | 0 | 0 | 1 | 9 |
| TD (812) | 0 | 0 | 0 | 2 | 3 | 6 |
| CDH (362) | 0 | 1 | 0 | 0 | 1 | 0 |
| CRAN (291) | 0 | 1 | 0 | 0 | 0 | 0 |
| PNH (202) | 1 | 0 | 0 | 0 | 0 | 0 |
| ALS (173) | 0 | 0 | 0 | 0 | 0 | 1 |
| BP (79) | 0 | 0 | 0 | 0 | 0 | 1 |
| EOPD (49) | 0 | 0 | 0 | 0 | 0 | 1 |
| CP (98) | 0 | 0 | 0 | 1 | 0 | 0 |
| NTD (43) | 0 | 0 | 0 | 1 | 0 | 0 |
| SMS (13) | 1 | 0 | 0 | 0 | 0 | 0 |
| CS (14) | 1 | 0 | 0 | 0 | 0 | 0 |
| AFD (4) | 0 | 1 | 0 | 0 | 0 | 0 |
| CD (19 012) | 117 | 27 | 46 | 60 | 47 | 88 |
| Total | 132 | 36 | 62 | 116 | 99 | 230 |
ASD, autism spectrum disorder; UDD, undiagnosed developmental disorder; CHD, congenital heart disorder; ID, intellectual disability; EE, epileptic encephalopathy; SCZ, schizophrenia; TD, tourette disorder; CDH, congenital diaphragmatic hernia; CRAN, craniosynostosis; PNH, periventricular nodular heterotopia; ALS, amyotrophic lateral sclerosis; BP, bipolar disorder; EOPD, early onset parkinson disease; CP, cerebral palsy; NTD, neural tube defects; SMS, smith-magenis syndrome; CS, cantu syndrome; AFD, acromelic frontonasal dysostosis. CD, combined all samples with different disorders. Number of genes with FDR < 0.2 in each disorder and cross disorders analysis were showed in this table. We ranked all candidate genes into six tiers based on the strength of false discovery rate (FDR). The total number of candidate genes were counted after removing redundancy.