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. 2019 Jul 15;47(16):8485–8501. doi: 10.1093/nar/gkz594

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Epigenetic regulation of MT2/MERVL after Zscan4c overexpression. (A–C) H3K4me1 (A), H3K27ac (B), and H3K14ac (C) profile plot around the centre of MT2 sequences in control ESCs (Control OE) and Zscan4c-overexpressed ESCs (Zscan4c OE). The ChIP-seq signal was calculated as the ratio of normalized reads relative to input. (D–F) ChIP-qPCR analysis of H3K4me1 (D), H3K27ac (E) and H3K14ac (F) enrichment on specific locus of MT2 in control ESCs and Zscan4c-overexpressed ESCs. LINE1, MTA and IAPEz were included as control. ChIP-qPCR data was normalized to input and that of LINE1. Biological-triplicate data (n = 3 extracts) are presented as mean ± s.e.m.