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. 2019 Jul 22;47(16):8675–8692. doi: 10.1093/nar/gkz613

Figure 8.

Figure 8.

Modulation of the RNMT active site upon binding of a truncated form of RAM (20–45). (A) Conformational dynamics of RNMT in complex with the truncated RAM (20–45). The representative simulation snapshot is superimposed with multiple structures (light grey) that were sampled from the entire aMD trajectory and illustrate the range of conformational dynamics. The key structural elements are labelled and coloured as in Figure 4B. (B) The community network diagram of the RNMT–RAM (2–45) complex. The representation is the same as in Figure 7B. (C) Left: Free energy landscape (FEL) of apo-RNMT in complex with the truncated RAM. Right: The representative structure of the RNMT active site corresponding to the ‘cap-open’ state. The representation is the same as in Figure 5. (D) Distribution of the volume of the cap (green) and AdoMet (magenta) binding pockets during the aMD simulation of apo-RNMT in complex with the truncated RAM. The representation is the same as in Figure 6.