Table 4.
Assay types and activity thresholds used for activity tag determination: only concentration based assays were used to determine activity tags. Activities reporting less than the maximum admitted value for positives were considered active (+) interactions, while those greater than the ‘minimum admitted value for negatives’ were considered inactive (−). Any activity reported in between these two values was considered as indeterminate (0)
Assay type |
Standard unit |
Maximum admitted value for actives | Minimum admitted value for inactives |
---|---|---|---|
AC50 | nM | 20000 | 100000 |
EC50 | nM | 20000 | 100000 |
IC50 | nM | 20000 | 100000 |
IC50 | ug ml−1 | 15 | 50 |
K d | nM | 20000 | 100000 |
K i | nM | 20000 | 100000 |
Potency | nM | 20000 | 100000 |