Table 1.

Ontological relationships used by CARD within the Antibiotic Resistance Ontology (ARO)

Relationship Label	Accession	Description4
is_a	n/a	An axiomatic relationship wherein the subject class A is a subclass of class B
part_of	BFO1:0000050	A relationship wherein a subject class A is but a part of class B
has_part	BFO:0000051	A relationship wherein a subject class A has a part class B (inverse of part_of)
participates_in	RO2:0000056	A relationship between continuant A and process B wherein A is somehow involved in B
regulates	RO:0002211	A relationships wherein the subject class A regulates the activity of class B
derives_from	RO:0001000	A relationship between class A and class B wherein B inherits many properties from A
evolutionary_variant_of	RO:0002321	A relationship wherein gene or protein A is a paralogous or orthologous variant of gene or protein B
confers_resistance_to_drug_class	Pending3	A relationship wherein the subject class A confers or contributes to antibiotic resistance to drug class B (formerly confers_resistance_to)
confers_resistance_to_antibiotic	Pending	A relationship wherein the subject class A confers or contributes to antibiotic resistance to antibiotic B (formerly confers_resistance_to_drug)
targeted_by	Pending	A relationship wherein molecule A is targeted by drug class B
targeted_by_antibiotic	Pending	A relationship wherein molecule A is targeted by antibiotic B (formerly targeted_by_drug)

¹Basic Formal Ontology (http://purl.obolibrary.org/obo/bfo).

²Relations Ontology (http://purl.obolibrary.org/obo/ro).

³Custom relationships for CARD used by ARO but not yet included in the Relations Ontology.

⁴Paraphrased from source.