Table 2.
ARO classification tags used to drive biocuration and provide easy interpretation of genome annotations
| Classification Tag | Requirement1 | Annotated ARO Terms | ARO Example2 |
|---|---|---|---|
| AMR Gene Family | Primary | 304 | NDM ß-lactamase (ARO:300057) |
| Drug Class | Primary | 49 | Aminoglycoside (ARO:0000016) |
| Resistance Mechanism | Primary | 7 | Antibiotic target replacement (ARO:0001002) |
| Antibiotic | Primary | 308 | Streptomycin (ARO:0000040) |
| Adjuvant | Secondary | 8 | Tazobactam (ARO:0000077) |
| Efflux Component | Secondary | 1 | Efflux pump complex or subunit (ARO:3000159) |
| Efflux Regulator | Secondary | 1 | Two-component regulatory system modulating efflux (ARO:3000451) |
1Primary tags are required for all CARD AMR determinants where applicable; secondary tags apply only rarely and can be omitted at the curator's discretion.
2Example names are abbreviated, see ARO accession in CARD for the complete description.