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. 2019 Nov 14;47(22):11755–11770. doi: 10.1093/nar/gkz992

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — FBXO47 is indispensable for telomere attachment. (A) Equator images of spermatocytes at zygotene, stained with the indicated antibodies. Arrowheads indicate internal telomeres and arrows indicate telomeres at the nuclear periphery. Scale bars, 10 μm. (B) Graphs showing the ratio of spermatocytes with telomeres detached from the INM. (C) Graphs showing the number of internal TRF1 foci per image (n > 30 cells for each genotype). Error bars, SEM, ***P < 0.001. (D) Electron microscopic images of telomeres (arrowheads) and INMs (arrows) in spermatocytes of the indicated genotypes, with schematics representing the structures. NE, nuclear envelope; AP, attachment plate; CH, chromatin; SC, synaptonemal complex. Scale bars, 200 nm.