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Schematic of meiosis-specific telomere shelterin protection in mammals. FBXO47 prevents TRF2 degradation as a ubiquitination inhibitor during meiosis and maintains telomere shelterin integrity for initial telomere attachment. The absence of FBXO47 destabilizes TRF2 during meiosis and disrupts telomere shelterin protein localization and attachment to the inner nuclear membrane.
