Table 1.

Gene ontology (GO) terms that suggest enhanced DNA damage and DNA damage responses in Lmna null MEFs, including responses to DNA damage repaired by BER

GO accession number	GO term	Z-score	P-value
GO0008152	Metabolic process	-4.215669497	0.00052508
GO0004030	Aldehyde dehydrogenase NAD(P)+ activity	-3.387727434	0.0046726
GO0006281	DNA repair	2.362503986	0.0011468
GO0000002	Mitochondrial Genome Maintenance*	2.054294833	0.0024042

Microarray analyses were performed on control and Lmna knockout MEFs, followed by Gene Ontology (GO) analysis of the downregulated and upregulated genes. For each pathway z-score, a P-value was computed using JMP 6.0 software to test for the significance of the z-score obtained.

*This GO term points to BER since mitochondria are exposed to persistent oxidative stress, and BER has a key role in counteracting mitochondrial oxidative DNA damage.