. 2019 Oct 24;47(22):11709–11728. doi: 10.1093/nar/gkz912

Table 3.

Effect of Lmna deletion on known base substitution fingerprints of persistent oxidative damage

Base substitution	Frequency (per 10⁴ bases)		Fold change
	MEF Lmna^+/+	MEF Lmna^−/−
C>A*	0.58	0.63	1.07
C>T**	0.78	0.91	1.16

Mutational analysis of genomic DNA isolated from Lmna^+/+ and Lmna^−/− MEFs that were treated with 50 μM H₂O₂ for 3 weeks. Frequencies represent the extent of substitution mutations at each locus in MEFs treated with H₂O₂, relative to the untreated condition. Fold change represents the effect of Lmna deletion on mutation frequency in the treated cells. The substitution mutation frequencies in H₂O₂-treated Lmna^−/− were significantly higher than the frequencies in H₂O₂-treated Lmna^+/+ MEFs (P< 0.001, unpaired t-test).

*Base substitution that reflects the GC>TA transversion mutations that result from 8-oxoG:A mismatches.

**Base substitution that reflects GC>AT transition mutations that often result from oxidative deamination of cytosines.