Table 2.

Results of univariate and multivariable logistic regression models examining predictors of advanced risk-reduction strategies.

	Breast: Risk-Reducing Mastectomy or Breast MRI (n=98)		Ovarian: Risk-Reducing Salpingo-oophorectomy, CA125 Test, or Transvaginal/Pelvic Ultrasound (n=140)
Predictors	Univariate	Multivariable	Univariate	Multivariable
Demographic Variables
Age	1.00 [0.90, 1.12]		0.97 [0.92, 1.03]
Country of Birth	0.29 [0.07, 1.30]		1.56 [0.64, 3.76]
Education	0.69 [0.07, 7.19]		1.90 [0.69, 5.25]
Marital Status	0.62 [0.18, 2.09]		1.52 [0.74, 3.10]
Employment Status	0.68 [0.20, 2.28]		1.22 [0.62, 2.40]
Insurance Status	1.04 [0.17, 6.35]		1.37 [0.51, 3.67]
Clinical Variables
Significant family history	2.15 [0.40, 11.56]		1.19 [0.56, 2.52]
Cancer Stage at Diagnosis
Localized	(ref)		(ref)
Regional	0.92 [0.26, 3.29]		0.91 [0.44, 1.85]
Distant	†		2.59 [0.23, 29.75]
Time since BC diagnosis	0.47** [0.24, 0.93]	0.47** [0.24, 0.93]	0.93 [0.81, 1.08]
Time since GT	0.87 [0.13, 11.06]		0.86 [0.24, 3.07]
Hormone Receptor Status
ER positive	0.62 [0.16, 2.37]		1.92* [0.89, 4.14]	2.42* [0.92, 1.62]
PR positive	0.67 [0.20, 2.30]		1.58 [0.77, 3.25]
HER2 positive	0.91 [0.22, 3.76]		0.67 [0.27, 1.66]
BRCA1/2 carrier status
BRCA negative	(ref)		(ref)	(ref)
VUS	3.85 [0.74, 20.13]		1.68 [0.79, 3.61]	2.04 [0.77, 5.37]
BRCA positive	†		4.48** [1.42, 14.20]	6.56** [1.44, 29.85]
Decision-making Variables
Absolute perceived risk (5%)	1.11** [0.99, 1.25]		1.02 [0.96, 1.08]
Relative perceived risk
Much lower	(ref)		(ref)	(ref)
A little lower	0.33 [0.04, 3.21]		1.47 [0.39, 5.55]	1.17 [0.25, 5.46]
About the same	0.75 [0.15, 3.84]		0.92 [0.38, 2.25]	0.45 [0.15, 1.32]
A little higher	0.33 [0.04, 3.21]		1.94 [0.68, 5.51]	1.08 [0.31, 3.75]
Much higher	2.33 [0.22, 25.25]		4.71** [1.10, 20.15]	9.41** [1.64, 54.05]
HBOC knowledge	1.04 [0.87, 1.24]		1.26** [1.11, 1.43]	1.36** [1.15, 1.62]

^*p < 0.1;

^**p < 0.05;

^†unable to be estimated