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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Hypertension. 2020 Mar 23;75(5):1315–1324. doi: 10.1161/HYPERTENSIONAHA.120.14736

Figure 2.

Figure 2.

Maternal CAP treatment alters gut microbiota in SHR male offspring. (A) Shannon diversity and Firmicutes/Bacteroidetes ratio (F/B ratio) were affected by CAP in 12-week-old SHR male offspring. (B) Principal coordinate analysis (PCoA) with unweighted UniFrac metric was used to present the dissimilarity of the groups. (C) Taxonomic structure and abundance of indicated phylotypes were analyzed by LefSe and presented in cladogram. Significant dominance of phylotypes in each group was indicated by color. (D) Abundance of individual bacterial genera with significant differences between the groups. OCAP, maternal treatment with captopril; SCAP, sustained treatment with captopril. n= 6–7 rats per group. Data are presented as mean ± SEM. * P<0.05; **P<0.01; ***P<0.001 in one-way ANOVA followed by Tukey’s multiple comparison.